As Artificial Intelligence (AI) becomes more dynamic and ubiquitous, it is dramatically empowering people in all walks of life while also giving rise to urgent questions about the future of humanity—a historic challenge whose contours and consequences are revealed by three eminent thinkers in Genesis. As it absorbs data, gains agency, and intermediates between humans and reality, AI will help us to address enormous crises, from climate change to geopolitical conflicts to income inequality. It might well solve some of the greatest mysteries of our universe, revolutionize fields as diverse as medicine and architecture, and elevate the human spirit to unimaginable heights. But it will also pose challenges on a scale and of an intensity that we have never seen—usurping our power of independent judgment and action, testing our relationship with the divine, and perhaps even spurring a new phase in human evolution. Whom will we choose to lead our species through this wilderness? Or have we, passively and unwittingly, already chosen? Charting a course between blind faith and unjustified fear, Genesis outlines an effective strategy for navigating the age of AI. The last book of elder statesman Henry Kissinger, written with technologists Eric Schmidt and Craig Mundie, it prepares the decisionmakers of today—that is, all of us—for the choices of tomorrow, and equips us to seize the opportunities presented by AI without falling prey to the darker forces that this revolution has unleashed.